Distant metastatic disease
Squamous cell carcinoma arising in the nasopharynx, salivary glands...
Prior treatment in the H & N area
Hypertension ( diastolic > 100 mm Hg) refractory to treatment
Symptomatic cardiovascular disease, deep vein thrombosis
Pregnant or breast feeding women
Medical or psychological condition that would not permit the patient to complete the trial or sign IC